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| Season | Week | Date | Time | Road | Home |
| 2022 | 1 | 8-Sep-2022 | 8:20 PM | Buffalo Bills | Los Angeles Rams |
| 2022 | 1 | 11-Sep-2022 | 1:00 PM | Baltimore Ravens | New York Jets |
| 2022 | 1 | 11-Sep-2022 | 1:00 PM | Cleveland Browns | Carolina Panthers |
| 2022 | 1 | 11-Sep-2022 | 1:00 PM | Indianapolis Colts | Houston Texans |
| 2022 | 1 | 11-Sep-2022 | 1:00 PM | Jacksonville Jaguars | Washington Commanders |
| 2022 | 1 | 11-Sep-2022 | 1:00 PM | New England Patriots | Miami Dolphins |
| 2022 | 1 | 11-Sep-2022 | 1:00 PM | New Orleans Saints | Atlanta Falcons |
| 2022 | 1 | 11-Sep-2022 | 1:00 PM | Philadelphia Eagles | Detroit Lions |
| 2022 | 1 | 11-Sep-2022 | 1:00 PM | Pittsburgh Steelers | Cincinnati Bengals |
| 2022 | 1 | 11-Sep-2022 | 1:00 PM | San Francisco 49ers | Chicago Bears |
| 2022 | 1 | 11-Sep-2022 | 4:25 PM | Green Bay Packers | Minnesota Vikings |
| 2022 | 1 | 11-Sep-2022 | 4:25 PM | Kansas City Chiefs | Arizona Cardinals |
| 2022 | 1 | 11-Sep-2022 | 4:25 PM | Las Vegas Raiders | Los Angeles Chargers |
| 2022 | 1 | 11-Sep-2022 | 4:25 PM | New York Giants | Tennessee Titans |
| 2022 | 1 | 11-Sep-2022 | 8:20 PM | Tampa Bay Buccaneers | Dallas Cowboys |
| 2022 | 1 | 12-Sep-2022 | 8:15 PM | Denver Broncos | Seattle Seahawks |
| 2022 | 2 | 15-Sep-2022 | 8:15 PM | Los Angeles Chargers | Kansas City Chiefs |
| 2022 | 2 | 18-Sep-2022 | 1:00 PM | Carolina Panthers | New York Giants |
| 2022 | 2 | 18-Sep-2022 | 1:00 PM | Indianapolis Colts | Jacksonville Jaguars |
| 2022 | 2 | 18-Sep-2022 | 1:00 PM | Miami Dolphins | Baltimore Ravens |
| 2022 | 2 | 18-Sep-2022 | 1:00 PM | New England Patriots | Pittsburgh Steelers |
| 2022 | 2 | 18-Sep-2022 | 1:00 PM | New York Jets | Cleveland Browns |
| 2022 | 2 | 18-Sep-2022 | 1:00 PM | Tampa Bay Buccaneers | New Orleans Saints |
| 2022 | 2 | 18-Sep-2022 | 1:00 PM | Washington Commanders | Detroit Lions |
| 2022 | 2 | 18-Sep-2022 | 4:05 PM | Atlanta Falcons | Los Angeles Rams |
| 2022 | 2 | 18-Sep-2022 | 4:05 PM | Seattle Seahawks | San Francisco 49ers |
| 2022 | 2 | 18-Sep-2022 | 4:25 PM | Arizona Cardinals | Las Vegas Raiders |
| 2022 | 2 | 18-Sep-2022 | 4:25 PM | Cincinnati Bengals | Dallas Cowboys |
| 2022 | 2 | 18-Sep-2022 | 4:25 PM | Houston Texans | Denver Broncos |
| 2022 | 2 | 18-Sep-2022 | 8:20 PM | Chicago Bears | Green Bay Packers |
| 2022 | 2 | 19-Sep-2022 | 7:15 PM | Tennessee Titans | Buffalo Bills |
| 2022 | 2 | 19-Sep-2022 | 8:30 PM | Minnesota Vikings | Philadelphia Eagles |
| 2022 | 3 | 22-Sep-2022 | 8:15 PM | Pittsburgh Steelers | Cleveland Browns |
| 2022 | 3 | 25-Sep-2022 | 1:00 PM | Baltimore Ravens | New England Patriots |
| 2022 | 3 | 25-Sep-2022 | 1:00 PM | Buffalo Bills | Miami Dolphins |
| 2022 | 3 | 25-Sep-2022 | 1:00 PM | Cincinnati Bengals | New York Jets |
| 2022 | 3 | 25-Sep-2022 | 1:00 PM | Detroit Lions | Minnesota Vikings |
| 2022 | 3 | 25-Sep-2022 | 1:00 PM | Houston Texans | Chicago Bears |
| 2022 | 3 | 25-Sep-2022 | 1:00 PM | Kansas City Chiefs | Indianapolis Colts |
| 2022 | 3 | 25-Sep-2022 | 1:00 PM | Las Vegas Raiders | Tennessee Titans |
| 2022 | 3 | 25-Sep-2022 | 1:00 PM | New Orleans Saints | Carolina Panthers |
| 2022 | 3 | 25-Sep-2022 | 1:00 PM | Philadelphia Eagles | Washington Commanders |
| 2022 | 3 | 25-Sep-2022 | 4:05 PM | Jacksonville Jaguars | Los Angeles Chargers |
| 2022 | 3 | 25-Sep-2022 | 4:25 PM | Atlanta Falcons | Seattle Seahawks |
| 2022 | 3 | 25-Sep-2022 | 4:25 PM | Green Bay Packers | Tampa Bay Buccaneers |
| 2022 | 3 | 25-Sep-2022 | 4:25 PM | Los Angeles Rams | Arizona Cardinals |
| 2022 | 3 | 25-Sep-2022 | 8:20 PM | San Francisco 49ers | Denver Broncos |
| 2022 | 3 | 26-Sep-2022 | 8:15 PM | Dallas Cowboys | New York Giants |
| 2022 | 4 | 29-Sep-2022 | 8:15 PM | Miami Dolphins | Cincinnati Bengals |
| 2022 | 4 | 2-Oct-2022 | 9:30 AM | Minnesota Vikings | New Orleans Saints |
| 2022 | 4 | 2-Oct-2022 | 1:00 PM | Buffalo Bills | Baltimore Ravens |
| 2022 | 4 | 2-Oct-2022 | 1:00 PM | Chicago Bears | New York Giants |
| 2022 | 4 | 2-Oct-2022 | 1:00 PM | Cleveland Browns | Atlanta Falcons |
| 2022 | 4 | 2-Oct-2022 | 1:00 PM | Jacksonville Jaguars | Philadelphia Eagles |
| 2022 | 4 | 2-Oct-2022 | 1:00 PM | Los Angeles Chargers | Houston Texans |
| 2022 | 4 | 2-Oct-2022 | 1:00 PM | New York Jets | Pittsburgh Steelers |
| 2022 | 4 | 2-Oct-2022 | 1:00 PM | Seattle Seahawks | Detroit Lions |
| 2022 | 4 | 2-Oct-2022 | 1:00 PM | Tennessee Titans | Indianapolis Colts |
| 2022 | 4 | 2-Oct-2022 | 1:00 PM | Washington Commanders | Dallas Cowboys |
| 2022 | 4 | 2-Oct-2022 | 4:05 PM | Arizona Cardinals | Carolina Panthers |
| 2022 | 4 | 2-Oct-2022 | 4:25 PM | Denver Broncos | Las Vegas Raiders |
| 2022 | 4 | 2-Oct-2022 | 4:25 PM | New England Patriots | Green Bay Packers |
| 2022 | 4 | 2-Oct-2022 | 8:20 PM | Kansas City Chiefs | Tampa Bay Buccaneers |
| 2022 | 4 | 3-Oct-2022 | 8:15 PM | Los Angeles Rams | San Francisco 49ers |
| 2022 | 5 | 6-Oct-2022 | 8:15 PM | Indianapolis Colts | Denver Broncos |
| 2022 | 5 | 9-Oct-2022 | 9:30 AM | New York Giants | Green Bay Packers |
| 2022 | 5 | 9-Oct-2022 | 1:00 PM | Atlanta Falcons | Tampa Bay Buccaneers |
| 2022 | 5 | 9-Oct-2022 | 1:00 PM | Chicago Bears | Minnesota Vikings |
| 2022 | 5 | 9-Oct-2022 | 1:00 PM | Detroit Lions | New England Patriots |
| 2022 | 5 | 9-Oct-2022 | 1:00 PM | Houston Texans | Jacksonville Jaguars |
| 2022 | 5 | 9-Oct-2022 | 1:00 PM | Los Angeles Chargers | Cleveland Browns |
| 2022 | 5 | 9-Oct-2022 | 1:00 PM | Miami Dolphins | New York Jets |
| 2022 | 5 | 9-Oct-2022 | 1:00 PM | Pittsburgh Steelers | Buffalo Bills |
| 2022 | 5 | 9-Oct-2022 | 1:00 PM | Seattle Seahawks | New Orleans Saints |
| 2022 | 5 | 9-Oct-2022 | 1:00 PM | Tennessee Titans | Washington Commanders |
| 2022 | 5 | 9-Oct-2022 | 4:05 PM | San Francisco 49ers | Carolina Panthers |
| 2022 | 5 | 9-Oct-2022 | 4:25 PM | Dallas Cowboys | Los Angeles Rams |
| 2022 | 5 | 9-Oct-2022 | 4:25 PM | Philadelphia Eagles | Arizona Cardinals |
| 2022 | 5 | 9-Oct-2022 | 8:20 PM | Cincinnati Bengals | Baltimore Ravens |
| 2022 | 5 | 10-Oct-2022 | 8:15 PM | Las Vegas Raiders | Kansas City Chiefs |
| 2022 | 6 | Bye | Detroit Lions | ||
| 2022 | 6 | Bye | Houston Texans | ||
| 2022 | 6 | Bye | Las Vegas Raiders | ||
| 2022 | 6 | Bye | Tennessee Titans | ||
| 2022 | 6 | 13-Oct-2022 | 8:15 PM | Washington Commanders | Chicago Bears |
| 2022 | 6 | 16-Oct-2022 | 1:00 PM | Baltimore Ravens | New York Giants |
| 2022 | 6 | 16-Oct-2022 | 1:00 PM | Cincinnati Bengals | New Orleans Saints |
| 2022 | 6 | 16-Oct-2022 | 1:00 PM | Jacksonville Jaguars | Indianapolis Colts |
| 2022 | 6 | 16-Oct-2022 | 1:00 PM | Minnesota Vikings | Miami Dolphins |
| 2022 | 6 | 16-Oct-2022 | 1:00 PM | New England Patriots | Cleveland Browns |
| 2022 | 6 | 16-Oct-2022 | 1:00 PM | New York Jets | Green Bay Packers |
| 2022 | 6 | 16-Oct-2022 | 1:00 PM | San Francisco 49ers | Atlanta Falcons |
| 2022 | 6 | 16-Oct-2022 | 1:00 PM | Tampa Bay Buccaneers | Pittsburgh Steelers |
| 2022 | 6 | 16-Oct-2022 | 4:05 PM | Arizona Cardinals | Seattle Seahawks |
| 2022 | 6 | 16-Oct-2022 | 4:05 PM | Carolina Panthers | Los Angeles Rams |
| 2022 | 6 | 16-Oct-2022 | 4:25 PM | Buffalo Bills | Kansas City Chiefs |
| 2022 | 6 | 16-Oct-2022 | 8:20 PM | Dallas Cowboys | Philadelphia Eagles |
| 2022 | 6 | 17-Oct-2022 | 8:15 PM | Denver Broncos | Los Angeles Chargers |
| 2022 | 7 | Bye | Buffalo Bills | ||
| 2022 | 7 | Bye | Los Angeles Rams | ||
| 2022 | 7 | Bye | Minnesota Vikings | ||
| 2022 | 7 | Bye | Philadelphia Eagles | ||
| 2022 | 7 | 20-Oct-2022 | 8:15 PM | New Orleans Saints | Arizona Cardinals |
| 2022 | 7 | 23-Oct-2022 | 1:00 PM | Atlanta Falcons | Cincinnati Bengals |
| 2022 | 7 | 23-Oct-2022 | 1:00 PM | Cleveland Browns | Baltimore Ravens |
| 2022 | 7 | 23-Oct-2022 | 1:00 PM | Detroit Lions | Dallas Cowboys |
| 2022 | 7 | 23-Oct-2022 | 1:00 PM | Green Bay Packers | Washington Commanders |
| 2022 | 7 | 23-Oct-2022 | 1:00 PM | Indianapolis Colts | Tennessee Titans |
| 2022 | 7 | 23-Oct-2022 | 1:00 PM | New York Giants | Jacksonville Jaguars |
| 2022 | 7 | 23-Oct-2022 | 1:00 PM | Tampa Bay Buccaneers | Carolina Panthers |
| 2022 | 7 | 23-Oct-2022 | 4:05 PM | Houston Texans | Las Vegas Raiders |
| 2022 | 7 | 23-Oct-2022 | 4:05 PM | New York Jets | Denver Broncos |
| 2022 | 7 | 23-Oct-2022 | 4:25 PM | Kansas City Chiefs | San Francisco 49ers |
| 2022 | 7 | 23-Oct-2022 | 4:25 PM | Seattle Seahawks | Los Angeles Chargers |
| 2022 | 7 | 23-Oct-2022 | 8:20 PM | Pittsburgh Steelers | Miami Dolphins |
| 2022 | 7 | 24-Oct-2022 | 8:15 PM | Chicago Bears | New England Patriots |
| 2022 | 8 | Bye | Kansas City Chiefs | ||
| 2022 | 8 | Bye | Los Angeles Chargers | ||
| 2022 | 8 | 27-Oct-2022 | 8:15 PM | Baltimore Ravens | Tampa Bay Buccaneers |
| 2022 | 8 | 30-Oct-2022 | 9:30 AM | Denver Broncos | Jacksonville Jaguars |
| 2022 | 8 | 30-Oct-2022 | 1:00 PM | Arizona Cardinals | Minnesota Vikings |
| 2022 | 8 | 30-Oct-2022 | 1:00 PM | Carolina Panthers | Atlanta Falcons |
| 2022 | 8 | 30-Oct-2022 | 1:00 PM | Chicago Bears | Dallas Cowboys |
| 2022 | 8 | 30-Oct-2022 | 1:00 PM | Las Vegas Raiders | New Orleans Saints |
| 2022 | 8 | 30-Oct-2022 | 1:00 PM | Miami Dolphins | Detroit Lions |
| 2022 | 8 | 30-Oct-2022 | 1:00 PM | New England Patriots | New York Jets |
| 2022 | 8 | 30-Oct-2022 | 1:00 PM | Pittsburgh Steelers | Philadelphia Eagles |
| 2022 | 8 | 30-Oct-2022 | 4:05 PM | Tennessee Titans | Houston Texans |
| 2022 | 8 | 30-Oct-2022 | 4:25 PM | New York Giants | Seattle Seahawks |
| 2022 | 8 | 30-Oct-2022 | 4:25 PM | San Francisco 49ers | Los Angeles Rams |
| 2022 | 8 | 30-Oct-2022 | 4:25 PM | Washington Commanders | Indianapolis Colts |
| 2022 | 8 | 30-Oct-2022 | 8:20 PM | Green Bay Packers | Buffalo Bills |
| 2022 | 8 | 31-Oct-2022 | 8:15 PM | Cincinnati Bengals | Cleveland Browns |
| 2022 | 9 | Bye | Cleveland Browns | ||
| 2022 | 9 | Bye | Dallas Cowboys | ||
| 2022 | 9 | Bye | Denver Broncos | ||
| 2022 | 9 | Bye | New York Giants | ||
| 2022 | 9 | Bye | Pittsburgh Steelers | ||
| 2022 | 9 | Bye | San Francisco 49ers | ||
| 2022 | 9 | 3-Nov-2022 | 8:15 PM | Philadelphia Eagles | Houston Texans |
| 2022 | 9 | 6-Nov-2022 | 1:00 PM | Buffalo Bills | New York Jets |
| 2022 | 9 | 6-Nov-2022 | 1:00 PM | Carolina Panthers | Cincinnati Bengals |
| 2022 | 9 | 6-Nov-2022 | 1:00 PM | Green Bay Packers | Detroit Lions |
| 2022 | 9 | 6-Nov-2022 | 1:00 PM | Indianapolis Colts | New England Patriots |
| 2022 | 9 | 6-Nov-2022 | 1:00 PM | Las Vegas Raiders | Jacksonville Jaguars |
| 2022 | 9 | 6-Nov-2022 | 1:00 PM | Los Angeles Chargers | Atlanta Falcons |
| 2022 | 9 | 6-Nov-2022 | 1:00 PM | Miami Dolphins | Chicago Bears |
| 2022 | 9 | 6-Nov-2022 | 1:00 PM | Minnesota Vikings | Washington Commanders |
| 2022 | 9 | 6-Nov-2022 | 4:05 PM | Seattle Seahawks | Arizona Cardinals |
| 2022 | 9 | 6-Nov-2022 | 4:25 PM | Los Angeles Rams | Tampa Bay Buccaneers |
| 2022 | 9 | 6-Nov-2022 | 8:20 PM | Tennessee Titans | Kansas City Chiefs |
| 2022 | 9 | 7-Nov-2022 | 8:15 PM | Baltimore Ravens | New Orleans Saints |
| 2022 | 10 | Bye | Baltimore Ravens | ||
| 2022 | 10 | Bye | Cincinnati Bengals | ||
| 2022 | 10 | Bye | New England Patriots | ||
| 2022 | 10 | Bye | New York Jets | ||
| 2022 | 10 | 10-Nov-2022 | 8:15 PM | Atlanta Falcons | Carolina Panthers |
| 2022 | 10 | 13-Nov-2022 | 9:30 AM | Seattle Seahawks | Tampa Bay Buccaneers |
| 2022 | 10 | 13-Nov-2022 | 1:00 PM | Cleveland Browns | Miami Dolphins |
| 2022 | 10 | 13-Nov-2022 | 1:00 PM | Denver Broncos | Tennessee Titans |
| 2022 | 10 | 13-Nov-2022 | 1:00 PM | Detroit Lions | Chicago Bears |
| 2022 | 10 | 13-Nov-2022 | 1:00 PM | Houston Texans | New York Giants |
| 2022 | 10 | 13-Nov-2022 | 1:00 PM | Jacksonville Jaguars | Kansas City Chiefs |
| 2022 | 10 | 13-Nov-2022 | 1:00 PM | Minnesota Vikings | Buffalo Bills |
| 2022 | 10 | 13-Nov-2022 | 1:00 PM | New Orleans Saints | Pittsburgh Steelers |
| 2022 | 10 | 13-Nov-2022 | 4:05 PM | Indianapolis Colts | Las Vegas Raiders |
| 2022 | 10 | 13-Nov-2022 | 4:25 PM | Arizona Cardinals | Los Angeles Rams |
| 2022 | 10 | 13-Nov-2022 | 4:25 PM | Dallas Cowboys | Green Bay Packers |
| 2022 | 10 | 13-Nov-2022 | 8:20 PM | Los Angeles Chargers | San Francisco 49ers |
| 2022 | 10 | 14-Nov-2022 | 8:15 PM | Washington Commanders | Philadelphia Eagles |
| 2022 | 11 | Bye | Jacksonville Jaguars | ||
| 2022 | 11 | Bye | Miami Dolphins | ||
| 2022 | 11 | Bye | Seattle Seahawks | ||
| 2022 | 11 | Bye | Tampa Bay Buccaneers | ||
| 2022 | 11 | 17-Nov-2022 | 8:15 PM | Tennessee Titans | Green Bay Packers |
| 2022 | 11 | 20-Nov-2022 | 1:00 PM | Carolina Panthers | Baltimore Ravens |
| 2022 | 11 | 20-Nov-2022 | 1:00 PM | Chicago Bears | Atlanta Falcons |
| 2022 | 11 | 20-Nov-2022 | 1:00 PM | Cleveland Browns | Buffalo Bills |
| 2022 | 11 | 20-Nov-2022 | 1:00 PM | Detroit Lions | New York Giants |
| 2022 | 11 | 20-Nov-2022 | 1:00 PM | Los Angeles Rams | New Orleans Saints |
| 2022 | 11 | 20-Nov-2022 | 1:00 PM | New York Jets | New England Patriots |
| 2022 | 11 | 20-Nov-2022 | 1:00 PM | Philadelphia Eagles | Indianapolis Colts |
| 2022 | 11 | 20-Nov-2022 | 1:00 PM | Washington Commanders | Houston Texans |
| 2022 | 11 | 20-Nov-2022 | 4:05 PM | Las Vegas Raiders | Denver Broncos |
| 2022 | 11 | 20-Nov-2022 | 4:25 PM | Dallas Cowboys | Minnesota Vikings |
| 2022 | 11 | 20-Nov-2022 | 4:25 PM | Kansas City Chiefs | Los Angeles Chargers |
| 2022 | 11 | 20-Nov-2022 | 8:20 PM | Cincinnati Bengals | Pittsburgh Steelers |
| 2022 | 11 | 21-Nov-2022 | 8:00 PM | San Francisco 49ers | Arizona Cardinals |
| 2022 | 12 | 24-Nov-2022 | 12:30 PM | Buffalo Bills | Detroit Lions |
| 2022 | 12 | 24-Nov-2022 | 4:30 PM | New York Giants | Dallas Cowboys |
| 2022 | 12 | 24-Nov-2022 | 8:20 PM | New England Patriots | Minnesota Vikings |
| 2022 | 12 | 27-Nov-2022 | 1:00 PM | Atlanta Falcons | Washington Commanders |
| 2022 | 12 | 27-Nov-2022 | 1:00 PM | Baltimore Ravens | Jacksonville Jaguars |
| 2022 | 12 | 27-Nov-2022 | 1:00 PM | Chicago Bears | New York Jets |
| 2022 | 12 | 27-Nov-2022 | 1:00 PM | Cincinnati Bengals | Tennessee Titans |
| 2022 | 12 | 27-Nov-2022 | 1:00 PM | Denver Broncos | Carolina Panthers |
| 2022 | 12 | 27-Nov-2022 | 1:00 PM | Houston Texans | Miami Dolphins |
| 2022 | 12 | 27-Nov-2022 | 1:00 PM | Tampa Bay Buccaneers | Cleveland Browns |
| 2022 | 12 | 27-Nov-2022 | 4:05 PM | Las Vegas Raiders | Seattle Seahawks |
| 2022 | 12 | 27-Nov-2022 | 4:05 PM | Los Angeles Chargers | Arizona Cardinals |
| 2022 | 12 | 27-Nov-2022 | 4:25 PM | Los Angeles Rams | Kansas City Chiefs |
| 2022 | 12 | 27-Nov-2022 | 4:25 PM | New Orleans Saints | San Francisco 49ers |
| 2022 | 12 | 27-Nov-2022 | 8:20 PM | Green Bay Packers | Philadelphia Eagles |
| 2022 | 12 | 28-Nov-2022 | 8:15 PM | Pittsburgh Steelers | Indianapolis Colts |
| 2022 | 13 | Bye | Arizona Cardinals | ||
| 2022 | 13 | Bye | Carolina Panthers | ||
| 2022 | 13 | 1-Dec-2022 | 8:15 PM | Buffalo Bills | New England Patriots |
| 2022 | 13 | 4-Dec-2022 | 1:00 PM | Cleveland Browns | Houston Texans |
| 2022 | 13 | 4-Dec-2022 | 1:00 PM | Denver Broncos | Baltimore Ravens |
| 2022 | 13 | 4-Dec-2022 | 1:00 PM | Green Bay Packers | Chicago Bears |
| 2022 | 13 | 4-Dec-2022 | 1:00 PM | Jacksonville Jaguars | Detroit Lions |
| 2022 | 13 | 4-Dec-2022 | 1:00 PM | New York Jets | Minnesota Vikings |
| 2022 | 13 | 4-Dec-2022 | 1:00 PM | Pittsburgh Steelers | Atlanta Falcons |
| 2022 | 13 | 4-Dec-2022 | 1:00 PM | Tennessee Titans | Philadelphia Eagles |
| 2022 | 13 | 4-Dec-2022 | 1:00 PM | Washington Commanders | New York Giants |
| 2022 | 13 | 4-Dec-2022 | 4:05 PM | Miami Dolphins | San Francisco 49ers |
| 2022 | 13 | 4-Dec-2022 | 4:05 PM | Seattle Seahawks | Los Angeles Rams |
| 2022 | 13 | 4-Dec-2022 | 4:25 PM | Kansas City Chiefs | Cincinnati Bengals |
| 2022 | 13 | 4-Dec-2022 | 4:25 PM | Los Angeles Chargers | Las Vegas Raiders |
| 2022 | 13 | 4-Dec-2022 | 8:20 PM | Indianapolis Colts | Dallas Cowboys |
| 2022 | 13 | 5-Dec-2022 | 8:15 PM | New Orleans Saints | Tampa Bay Buccaneers |
| 2022 | 14 | Bye | Atlanta Falcons | ||
| 2022 | 14 | Bye | Chicago Bears | ||
| 2022 | 14 | Bye | Green Bay Packers | ||
| 2022 | 14 | Bye | Indianapolis Colts | ||
| 2022 | 14 | Bye | New Orleans Saints | ||
| 2022 | 14 | Bye | Washington Commanders | ||
| 2022 | 14 | 8-Dec-2022 | 8:15 PM | Las Vegas Raiders | Los Angeles Rams |
| 2022 | 14 | 11-Dec-2022 | 1:00 PM | Baltimore Ravens | Pittsburgh Steelers |
| 2022 | 14 | 11-Dec-2022 | 1:00 PM | Cleveland Browns | Cincinnati Bengals |
| 2022 | 14 | 11-Dec-2022 | 1:00 PM | Houston Texans | Dallas Cowboys |
| 2022 | 14 | 11-Dec-2022 | 1:00 PM | Jacksonville Jaguars | Tennessee Titans |
| 2022 | 14 | 11-Dec-2022 | 1:00 PM | Minnesota Vikings | Detroit Lions |
| 2022 | 14 | 11-Dec-2022 | 1:00 PM | New York Jets | Buffalo Bills |
| 2022 | 14 | 11-Dec-2022 | 1:00 PM | Philadelphia Eagles | New York Giants |
| 2022 | 14 | 11-Dec-2022 | 4:05 PM | Miami Dolphins | Los Angeles Chargers |
| 2022 | 14 | 11-Dec-2022 | 4:25 PM | Carolina Panthers | Seattle Seahawks |
| 2022 | 14 | 11-Dec-2022 | 4:25 PM | Tampa Bay Buccaneers | San Francisco 49ers |
| 2022 | 14 | 11-Dec-2022 | 8:20 PM | Kansas City Chiefs | Denver Broncos |
| 2022 | 14 | 12-Dec-2022 | 8:15 PM | New England Patriots | Arizona Cardinals |
| 2022 | 15 | 15-Dec-2022 | 8:15 PM | San Francisco 49ers | Seattle Seahawks |
| 2022 | 15 | 18-Dec-2022 | 1:00 PM | Atlanta Falcons | New Orleans Saints |
| 2022 | 15 | 18-Dec-2022 | 1:00 PM | Baltimore Ravens | Cleveland Browns |
| 2022 | 15 | 18-Dec-2022 | 1:00 PM | Dallas Cowboys | Jacksonville Jaguars |
| 2022 | 15 | 18-Dec-2022 | 1:00 PM | Detroit Lions | New York Jets |
| 2022 | 15 | 18-Dec-2022 | 1:00 PM | Indianapolis Colts | Minnesota Vikings |
| 2022 | 15 | 18-Dec-2022 | 1:00 PM | Kansas City Chiefs | Houston Texans |
| 2022 | 15 | 18-Dec-2022 | 1:00 PM | Miami Dolphins | Buffalo Bills |
| 2022 | 15 | 18-Dec-2022 | 1:00 PM | New York Giants | Washington Commanders |
| 2022 | 15 | 18-Dec-2022 | 1:00 PM | Philadelphia Eagles | Chicago Bears |
| 2022 | 15 | 18-Dec-2022 | 1:00 PM | Pittsburgh Steelers | Carolina Panthers |
| 2022 | 15 | 18-Dec-2022 | 4:05 PM | Arizona Cardinals | Denver Broncos |
| 2022 | 15 | 18-Dec-2022 | 4:25 PM | Cincinnati Bengals | Tampa Bay Buccaneers |
| 2022 | 15 | 18-Dec-2022 | 4:25 PM | Tennessee Titans | Los Angeles Chargers |
| 2022 | 15 | 18-Dec-2022 | 8:20 PM | New England Patriots | Las Vegas Raiders |
| 2022 | 15 | 19-Dec-2022 | 8:15 PM | Los Angeles Rams | Green Bay Packers |
| 2022 | 16 | 22-Dec-2022 | 8:15 PM | Jacksonville Jaguars | New York Jets |
| 2022 | 16 | 24-Dec-2022 | 1:00 PM | Atlanta Falcons | Baltimore Ravens |
| 2022 | 16 | 24-Dec-2022 | 1:00 PM | Buffalo Bills | Chicago Bears |
| 2022 | 16 | 24-Dec-2022 | 1:00 PM | Cincinnati Bengals | New England Patriots |
| 2022 | 16 | 24-Dec-2022 | 1:00 PM | Detroit Lions | Carolina Panthers |
| 2022 | 16 | 24-Dec-2022 | 1:00 PM | Houston Texans | Tennessee Titans |
| 2022 | 16 | 24-Dec-2022 | 1:00 PM | New Orleans Saints | Cleveland Browns |
| 2022 | 16 | 24-Dec-2022 | 1:00 PM | New York Giants | Minnesota Vikings |
| 2022 | 16 | 24-Dec-2022 | 1:00 PM | Seattle Seahawks | Kansas City Chiefs |
| 2022 | 16 | 24-Dec-2022 | 4:05 PM | Washington Commanders | San Francisco 49ers |
| 2022 | 16 | 24-Dec-2022 | 4:25 PM | Philadelphia Eagles | Dallas Cowboys |
| 2022 | 16 | 24-Dec-2022 | 8:15 PM | Las Vegas Raiders | Pittsburgh Steelers |
| 2022 | 16 | 25-Dec-2022 | 1:00 PM | Green Bay Packers | Miami Dolphins |
| 2022 | 16 | 25-Dec-2022 | 4:30 PM | Denver Broncos | Los Angeles Rams |
| 2022 | 16 | 25-Dec-2022 | 8:20 PM | Tampa Bay Buccaneers | Arizona Cardinals |
| 2022 | 16 | 26-Dec-2022 | 8:15 PM | Los Angeles Chargers | Indianapolis Colts |
| 2022 | 17 | 29-Dec-2022 | 8:15 PM | Dallas Cowboys | Tennessee Titans |
| 2022 | 17 | 1-Jan-2023 | 1:00 PM | Arizona Cardinals | Atlanta Falcons |
| 2022 | 17 | 1-Jan-2023 | 1:00 PM | Carolina Panthers | Tampa Bay Buccaneers |
| 2022 | 17 | 1-Jan-2023 | 1:00 PM | Chicago Bears | Detroit Lions |
| 2022 | 17 | 1-Jan-2023 | 1:00 PM | Cleveland Browns | Washington Commanders |
| 2022 | 17 | 1-Jan-2023 | 1:00 PM | Denver Broncos | Kansas City Chiefs |
| 2022 | 17 | 1-Jan-2023 | 1:00 PM | Indianapolis Colts | New York Giants |
| 2022 | 17 | 1-Jan-2023 | 1:00 PM | Jacksonville Jaguars | Houston Texans |
| 2022 | 17 | 1-Jan-2023 | 1:00 PM | Miami Dolphins | New England Patriots |
| 2022 | 17 | 1-Jan-2023 | 1:00 PM | New Orleans Saints | Philadelphia Eagles |
| 2022 | 17 | 1-Jan-2023 | 1:00 PM | Pittsburgh Steelers | Baltimore Ravens |
| 2022 | 17 | 1-Jan-2023 | 4:05 PM | New York Jets | Seattle Seahawks |
| 2022 | 17 | 1-Jan-2023 | 4:05 PM | San Francisco 49ers | Las Vegas Raiders |
| 2022 | 17 | 1-Jan-2023 | 4:25 PM | Minnesota Vikings | Green Bay Packers |
| 2022 | 17 | 1-Jan-2023 | 8:20 PM | Los Angeles Rams | Los Angeles Chargers |
| 2022 | 17 | 2-Jan-2023 | 8:30 PM | Buffalo Bills | Cincinnati Bengals |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Arizona Cardinals | San Francisco 49ers |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Baltimore Ravens | Cincinnati Bengals |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Carolina Panthers | New Orleans Saints |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Cleveland Browns | Pittsburgh Steelers |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Dallas Cowboys | Washington Commanders |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Detroit Lions | Green Bay Packers |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Houston Texans | Indianapolis Colts |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Kansas City Chiefs | Las Vegas Raiders |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Los Angeles Chargers | Denver Broncos |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Los Angeles Rams | Seattle Seahawks |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Minnesota Vikings | Chicago Bears |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | New England Patriots | Buffalo Bills |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | New York Giants | Philadelphia Eagles |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | New York Jets | Miami Dolphins |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Tampa Bay Buccaneers | Atlanta Falcons |
| 2022 | 18 | 8-Jan-2023 | 1:00 PM | Tennessee Titans | Jacksonville Jaguars |